More recent evolutions include the identification of the double expressor (DEL) DLBCL subtype, characterized by an overexpression of MYC and BCL2 proteins not related to underlying chromosomal rearrangement, and double-hit lymphomas (DHL), a separate entity defined as a dual rearrangement of MYC and BCL2 and/or BCL6, both associated with poor prognosis (1, 9). The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.