Furthermore, a cytokine array analysis showed increased Il33 and Cst3 expression in both tumor and serum from KPC-Cdh11+/+ mice compared to KPC-Cdh11+/- mice, while Il11 was highly enriched in KPC-Cdh11+/+ serum alone and Ccl11 was enriched in tumor alone (Figure 2E). Here, IL33 is linked to neoplasm.