Different signaling pathways involved in RT-induced mucositis and dermatitis have been identified, and they may contribute to RT-induced inflammatory pain, such as: nuclear factor-κB (NF-κB) signaling which upregulates other pathways such as COX2 pathway and downstream tyrosine kinase receptor pathways (e.g., PI3K/AKT signaling and MAPK signaling). The gene discussed is NFKB1; the disease is skin disorder.