Other cell signaling pathways including cell cycle and NF-kB pathway (CCND1) [67], autophagy (ATG16L2, ATG10) [62], wnt/β-catenin (APC, GSK3β) [70] and angiogenesis (EDN1) [68] regulating genes were associated with RT related acute mucositis and dermatitis. This evidence concerns the gene APC and skin disorder.