In recent years, an increasing number of recent studies have demonstrated that the innate immune system plays a critical role in the development and progression of RA and that a variety of innate immune cells, including monocytes, macrophages, dendritic cells, autoreactive CD4+ T cells and pathogenic B cells, are involved in the inflammatory response in RA patients, which in turn activates the adaptive immune system (Edilova et al., 2021; Jang et al., 2022). This evidence concerns the gene CD4 and rheumatoid arthritis.