RYR1 and Alzheimer disease: Similarly, when exploring the relationship between tsRNA and Alzheimer’s disease, researchers discovered that tRF-Thr-CGT-003 and tRF-Leu-CAA-004 in APP/PS1 transgenic mice might act on the mRNA of CACNG2 and RYR1 genes and subsequently influence the expression of calcium-regulated associated proteins they encode, such as voltage-gated calcium channel γ2 subunit and RyR1 proteins (Lu et al., 2021).