Other histone methylating genes, such as KMT5B/EZH1/KMT2D/KMT2E/SETD5, were also included in brown module, and related to pathological process or prognosis of myeloid neoplasms (MDS/AML) (Mochizuki-Kashio et al., 2015; Jin et al., 2020; Liquori et al., 2020; Janusz et al., 2021; Lin et al., 2021; Zhong et al., 2021). The gene discussed is KMT2D; the disease is acute myeloid leukemia.