The brown module included 1,301 genes, including ASXL1 (Gelsi-Boyer et al., 2009; Mills et al., 2009), ASXL2 (Li et al., 2017), ATR (Nguyen et al., 2018), CUX1 (An et al., 2018; Aly et al., 2019), DNMT3A (Walter et al., 2011), FLT3 (Daver et al., 2019), HOXA7 (Drabkin et al., 2002) and WT1 (Rautenberg et al., 2019), which are dysregulated and/or prognostic in MDS or AML. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.