TREML2 and Cognitive impairment: With the exception of this individual, all other carriers had substitutions at loci rs3851179 (intergenic, chromosome 11), rs3747742 (TREML2 missense variant, chromosome 6), and rs1990621 (intergenic, chromosome 7), which previously have been shown to be protective against cognitive impairment (Seto et al., 2021).