Other genes observed in the various adORS models and supported by AD-related literature include PTPN5 and VAT1L. PTPN5 (seen in Figure 2; Supplementary Figures 3A–D) is involved in pathways that regulate neuronal signal transduction, neuronal maturation and survival, synaptic function, and learning and memory. The gene discussed is PTPN5; the disease is Alzheimer disease.