APOE and Alzheimer disease: While a similar increase in performance was observed from adORSCNAD (AUROC = 0.634) to adORS.with.APOECNAD (AUROC = 0.750), the higher performance values from the adORS models overall, and in comparison to APOE.only (AUROC = 0.707), demonstrate that additional genes are contributing to AD prediction more than they may be in the PRS models (Table 3).