CD40LG and B-cell chronic lymphocytic leukemia: Other causes of Type 1 cryoglobulinemia include Waldenström macroglobulinemia, non-Hodgkin lymphoma, and chronic lymphocytic leukemia.77 Type 2 consists of monoclonal IgM with rheumatoid factor activity and polyclonal IgG, and Type 3 involves polyclonal IgM with rheumatoid factor activity and polyclonal IgG.78