Higher levels of pro-inflammatory cytokines, including IL-1, IL-2, IL-4, IL-6, IL-7, IL-10, IL-13, IL-17, M-CSF, G-CSF, GM-CSF, and IP-10 have been reported in severe COVID-19 patients (Costela-Ruiz et al., 2020).The NOD-like receptor protein 3(NLRP-3) inflammasome is a key immuno-stimulator with multi-organ effects through dysfunctional immuno-inflammatory pathways in COVID-19 (Rodrigues et al., 2021; Dutta et al., 2022). The gene discussed is NLRP3; the disease is COVID-19.