For example, miR‐138 was capable of targeting immune checkpoints consisting of CTLA‐4 and PD‐1 in gliomas and exerted anti‐glioma effects180; sponging to miR‐138, circ_002136, and circFOXO3 could regulate tumor progression and may have potential to target immune checkpoints to modulate immune in gliomas.157, 181. The gene discussed is CTLA4; the disease is central nervous system cancer.