circ‐0001801, hsa_circ_0043278, hsa_circ_0006168, circ_0001588, circMELK, circSERPINE2, circLGMN, and circ‐PITX1 were significantly up‐regulated in glioblastoma (GBM) and accelerated the glioma tumorigenesis via miR‐628‐5p/HMGB3,122 miRNA‐638/HOXA9,123 miR‐628‐5p/IGF1R,124 miR‐211‐5p/YY1, and miR‐1281/ERBB4,125, 126 miR‐593/EphB2,127 miR‐361‐3p/miR‐324‐5p/BCL2,128 miR‐127‐3p/LGMN,129 miR‐379‐5p/MAP3K2130 axis. This evidence concerns the gene EPHB2 and glioblastoma.