Administration of a small non‐antihypertensive dose of AT1 receptor blocker candesartan (0.1 mg/kg) in mice for 15 days inhibits LPS‐induced memory impairment by increasing expression of the BDNF/TrkB axis, which inhibits TLR4 and NF‐κB.159. The gene discussed is NTRK2; the disease is memory impairment.