SPAM1 and neoplasm: By using a clinically formulated PEGylated human recombinant PH20 hyaluronidase (PEGPH20) to deplete HA, the authors showed that HA degradation significantly impacts IFP leading to a dramatic increase in vessel diameter, which in turn allows high concentrations of chemotherapy to reach the tumor, thereby improving the cytotoxic effects of the antineoplastic drugs.