In head and neck squamous cell carcinoma (HNSCC), the transcription factor ΔNp63, a member of the p53 family that is widely expressed and deregulated in cancer [42, 43, 44, 45, 46, 47, 48, 49], binds to a specific p63‐binding site (p63 BS) in the promoter region of the HAS3 gene. Here, HAS3 is linked to head and neck squamous cell carcinoma.