For instance, in ovarian cancer and breast cancer cells, HA interacts with CD44 to promoting the formation of a complex between CD44, Nanog, and STAT‐3, which in turn induces the expression of SOX2, REX1, and MDR1, enhancing thus resistance to doxorubicin and paclitaxel [109]. This evidence concerns the gene ABCB1 and breast carcinoma.