STK11 and neoplasm: For the effects of hepatocytic Lkb1 depletion in circLARP1B−/− HCC mice (Figure 10a–c), the restoration of liver tumor numbers and the Vim and Ecad IHC in liver tumors indicate that Lkb1 depletion in hepatocytes promotes malignant transformation; the restoration of liver tumor size indicates that Lkb1 depletion also promotes tumor growth.