To provide further insights for HCC metastatic roles of circLARP1B in liver cells, we infused hepatocyte‐directed AAV8 expressing shRNA against circLARP1B (AAV8‐shcircLARP1B) or the corresponding negative control (AAV8‐shCtrl) into WT mice after DEN induction for 10 weeks (Figure 9a; Figure S3e, Supporting Information).[71] In livers of WT mice infused with AAV8‐shcircLARP1B, effective knockdown of circLARP1B was observed, while the Larp1b mRNA was unaltered (Figure 9b). Here, LARP1B is linked to hepatocellular carcinoma.