We have uncovered that circLARP1B disturbs heterogeneous nuclear ribonucleoprotein D (HNRNPD) from the binding to 3′ UTR of liver kinase B1 (LKB1), which leads to destabilizing LKB1 mRNA and then modulating a pathway pivotal to HCC metastasis and lipid metabolism. The gene discussed is STK11; the disease is hepatocellular carcinoma.