Presumably upstream mechanisms might upregulate both HNRNPD and circLARP1B in metastatic HCC (Figure 1g), and the two regulators had opposite effects on the levels of LKB1 mRNA, with HNRNPD enhancing and circLARP1B destabilizing LKB1 mRNA. This evidence concerns the gene STK11 and hepatocellular carcinoma.