The results of current study revealed a highly significant (p < 0.001) increase in the levels of CRP (76.29 ± 25.50), IL-6 (383.49 ± 213.84), PCT (0.82 ± 0.35), and LDH (480.43 ± 96.08) in the sera of nonsurvival severe COVID-19 patients when compared to survival severe COVID-19 patients (59.81 ± 16.69; 63.75 ± 44.71; 0.19 ± 0.14 and 273.54 ± 99.68; respectively). This evidence concerns the gene IL6 and COVID-19.