The ROC analysis demonstrated that in plasma exosomes from NSCLC patients with metastasis, CFHR5, C9, and MBL2 exhibited area under the curve (AUC) values of 0.855, 0.713, and 0.680, respectively, when compared to both the healthy control group and nonmetastatic NSCLC (Fig. 6A-C). This evidence concerns the gene CFHR5 and non-small cell lung carcinoma.