The panel of CFHR5, C9, and MBL2 markers exhibited predictive capabilities for PFS in NSCLC patients (p < 0.05), and CFHR5 also showed significant predictive value for OS (p < 0.05), indicating its potential as a predictive biomarker for metastasis (Fig. 7A). This evidence concerns the gene CFHR5 and non-small cell lung carcinoma.