CTSZ and colorectal carcinoma: KMT2A/KMT2D, KMT2C/KMT2B, SETd1A/SETd1B are the three pairs of KMT members that play significant role in tumorigenesis.471 KMT2 family mutations has been positively correlated with CRC progression.472 It has been documented that KMT2A interacts with p65 transcription factor (p65 is also known as nuclear factor NF-kappa-B), which is essential for its recruitment on the promoter region of CATHEPSIN Z (CTSZ), which is one of the important downstream targets of KMT2A.