Moreover, in comparison to normal esophageal epithelium, ZNF282 has been frequently reported to be overexpressed in ESCC tissues and ZNF282 depletion increased apoptosis and promoted cell cycle arrest at G1/S, suggesting that ZNF282 transcriptional co-activator, plays pivotal role in controlling E2F1-mediated ESCC progression.517. The gene discussed is E2F1; the disease is esophageal squamous cell carcinoma.