Transcriptional co-activator TRIM24 has been shown to drive cell cycle progression and upregulate CYCLIN D1 and p-Rb expression in HNSCC, suggesting that TRIM24 is involved in HNSCC progression through regulation of cell cycle related proteins.450 Cui et al.451 reported that TRIM24 variants were highly expressed in 56 HNSCC samples (P < 0.001). Here, RB1 is linked to head and neck squamous cell carcinoma.