CREB-binding protein (CBP) and its paralog, E1A-binding protein (p300) are highly conserved transcriptional coactivator with four transactivation domains that mediate interaction with transcription factors.429 These co-activators contain histone acetyltransferase (HAT) activity, which enables them to acetylate various non-histone transcription-related proteins such as p53.430 Overexpression of CBP/p300 is considered as a poor prognosis indicator for lung cancer patients.431 Activation and upregulation of human telomerase reverse transcriptase (hTERT) is a hallmark of lung cancer. The gene discussed is EP300; the disease is lung cancer.