SETD7 and plasma cell myeloma: NEAT1 lncRNA forms a complex with BRD4 and WDR5 and maintains them in a less-active state.253 In multiple myeloma, dual luciferase reporter assay showed that H19 inhibits miR-152-3p to enhance BRD4 expression.254 There is also evidence suggesting negative regulation of BRD4 by miR-141-3p.255 In ovarian cancer, SET7 has been shown to be modulated by miR-153, and lncRNA SNHG6 has been found to downregulate SETD7 by posttranscriptional destabilization.256