Contrarily, another study reported that the loss of CBP in the hypothalamus resulted in obesity.341 Hu et al.342 predicted a mechanism of BRD4-induced obesity through peroxisome proliferator-activated receptor ɣ (PPARɣ)-dependent growth differentiation factor 3 (GDF3) regulation. The gene discussed is GDF3; the disease is obesity due to melanocortin 4 receptor deficiency.