ISG15 and cancer: One more study found TRIM29 stabilizes interferon-stimulated gene 15 (ISG15) and promote cancer stem cell-like phenotype in pancreatic ductal adenocarcinomas (PDACs).545 Recent findings have suggested the involvement of YAP/TAZ in stemness maintenance and their deregulation may induce transformation of the cancer cells into CSCs.546 It is now quite evident that the co-activators not only take part in tumor growth but are also responsible for cancer stem cell fueled metastasis, drug resistance and unresponsiveness to therapies.