PIK3CA and hepatocellular carcinoma: BRD4, for example, interacts with different proteins under specific circumstances and therefore, regulate multiple cellular pathways.241 Mechanistically, Yu et al.241 revealed that in hepatocellular carcinoma, DDX5 forms transcriptional regulatory complex in association with BRD4 to positively regulate transcription of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA).