By means of dimethylated histone H3 K79, DOTL1 facilitates histone H4 acetylation, consequently regulating the binding of BRD4 to chromatin Moreover, inhibition of BRD4 activity was found to suppress proliferation in the majority of patients with chronic phase CML.463. Here, BRD4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.