Upon H. pylori infection, an increase in both TAZ nuclear expression and transcriptional activity of transcriptional enhancer TEA domain (TEAD) transcription factors was observed, which in turn induced EMT, invasion, and cancer stem cell-like properties.499 It has also been observed that a ubiquitously expressed protein tyrosine phosphatase, SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) interacts with the transcriptional co-activators YAP/TAZ, which in turn promotes its nuclear localization. Here, YAP1 is linked to cancer.