RPS6KB1 and cancer: DDX5, DEAD (Asp-Glu-Ala-Asp) box helicase 5 is a transcriptional co-activator that is overexpressed in different malignancies and associated with progression of cancer.508 It has been reported that in gastric cancer tissues, DDX5 is dramatically upregulated, and its overexpression correlates with gastric cancer cell growth and invasion.509 It has also been observed that DDX5 promotes cell proliferation by upregulating mTOR/S6K1 signaling activity, stipulating that targeting DDX5/mTOR/S6K1 might be a novel therapeutic approach for the treatment of gastric cancer.510