Using the ovarian cancer cell line SKOV3, it has been reported that Staphylococcal nuclease domain-containing protein 1 (SND1) regulates the gene transcriptional activation of SLUG (an epithelial-to-mesenchymal transition marker) by increasing chromatin accessibility through the recruitment of the acetyltransferases GCN5 and CBP/p300 to the SLUG promoter proximal region.403 Moreover, physical association of BRCA1 was observed with the transcriptional co-activators/acetyltransferases p300 and CBP. This evidence concerns the gene EP300 and ovarian cancer.