Chromosomal instability (CIN) is a hallmark of colorectal cancer, which results in copy number alterations (CNAs).466 DDX27, transcriptional co-activator is significantly upregulated and has extremely high frequency of copy number gain in colorectal cancer (CRC), and has also been found to be upregulated in CRC tissues.467 A study by Tang et al.468 has identified NF-κB pathway as the principal target of DDX27 in CRC. The gene discussed is DDX27; the disease is cervical squamous intraepithelial neoplasia.