The nuclear SMAD3 interacts with CBP/p300 to regulate the transcription of ZEB1, thereby promoting malignancy of early-stage lung adenocarcinoma.433 Moreover, it has also been documented that p300 in association with CREB suppress lipid peroxidation by binding to the GPX4 (glutathione peroxidase 4) promoter region, which further inhibits ferroptosis in lung adenocarcinoma.434 Hence, overexpression of CBP corresponds to poor prognosis in lung cancers. The gene discussed is EP300; the disease is lung cancer.