In sporadic CRC, a SNP located in the YAP1 gene has been identified as a common genetic risk variant with a hazard ratio of 1.05 and over expression of YAP1 is associated with shorter survival.478 It has been documented in β-CATENIN-driven colorectal cancer, that YES1 (a tyrosine kinase) phosphorylates YAP1 on Y357, subsequently promoting YAP1 nuclear localization and activation. This evidence concerns the gene YAP1 and colorectal cancer.