Mechanistically, upon activation, CRTC1 interacts with the CREB transcription factor and enhances the expression of CREB target genes like LYPD3, a high-glycosylated cell surface protein,513 ultimately augmenting cell migration and invasion, which contributes to esophageal cancer progression.514 On the other hand, CRTC2 in cooperation with CBP/p300 deposits acetylation marks on histones at inflammatory gene loci, consequently promoting active transcription and cytokine expression. Here, CREBBP is linked to esophageal cancer.