It has been reported that, upregulation of hTERT expression and tumor growth in lung adenocarcinoma cells is mediated by CBP, which binds to hTERT promoter and upregulates its transcription.432 Another study conducted by Zhang et al.433 reported that lncRNA LINC01977 interacts with SMAD3 and induces its nuclear transport. Here, SMAD3 is linked to lung adenocarcinoma.