E2F1 transcription factor is a key player that modulates cell cycle, DNA damage response, and apoptosis.516 It has been observed that ZNF282 (Zinc finger protein 282) functions as an E2F1 co-activator in esophageal squamous-cell carcinoma (ESCC), inducing accelerated transcription of E2F1 target genes like CCND2, CCNA1, CDC2, and CDC6, facilitating G1/S transition and cell cycle progression. Here, E2F1 is linked to esophageal squamous cell carcinoma.