TEAD4 and cancer: The active YAP1 transcriptional co-activator then interacts and forms a ternary complex with the transcription factor TBX5 and β-CATENIN to promote CRC survival and progression.479 Furthermore, YAP/TAZ-TEAD4 complex has been documented to transcriptionally upregulate the expression of CCBE1 (collagen and calcium-binding EGF domain 1) by binding to CCBE1 enhancer region of both CRC cells and cancer-associated fibroblasts.