NCOA1 and obesity due to melanocortin 4 receptor deficiency: Moreover, downregulation of p/CIP and SRC-1 was found to enhance insulin sensitivity and increase glucose uptake in both regular and high fat diet-fed p/CIP and SRC-1 double knockout (DKO) mice,336 indicating that targeting these diverse co-activators, is a promising pharmacological target for treatment of both type 2 diabetes and obesity.