BRD4 and malignant colon neoplasm: Targeting BRD4 resulted in significant downregulation in the expression of MYC proto-oncogene, restraining colon cancer progression.475 Wang et al.476 observed that in CRC, BRD4 phosphorylation has been reported to promote interaction with STAT3 to subsequently induce chromatin remodeling through enhanced binding interactions with enhancers and super-enhancers, thereby supporting a tumor-promoting transcriptional program.