CREB1 and cancer: As a matter of fact, overexpression of CRTC2 leads to higher physical interactions between CREB and CRCT2, accentuating the CREB downstream signaling, which is essential for a several cancer-associated adaptive response like glucose metabolism, cell growth, survival, immune evasion, and the maintenance of cancer stem cells.447 It has also been reported that in salivary mucoepidermoid carcinoma (MEC), frequent CRTC1/3-MAML2 fusions were observed.