The transcriptional co-activators CBP/p300 mediates increased acetylation of H3K18 and H3K27 in HCC tissues.490 It has been reported that the transcription factors HIF-1α and STAT3 can maximally induce transcription of VEGF when in association with CBP/p300 co-activator. This evidence concerns the gene CREBBP and hepatocellular carcinoma.