Recently, in intestinal tumorigenesis, co-activator MLL1 was observed to govern WNT/β-Catenin induced cancer stemness.539 KDM2A in breast cancer enhances stemness and angiogenesis by Jagged1 (JAG1) dependent mechanism.540 Another lysine demethylase KDM6B has been reported to enhance stemness related genes like SOX2, SOX9, and OCT4.541 Li et al.542 identified JMJD3 as one of the main drivers of esophageal squamous cell carcinoma pathogenesis through JMJD3/MYC/miR-17–92 pathway and regulate stemness and sensitivity to therapy. The gene discussed is SOX2; the disease is breast cancer.