CX3CR1 and Nephropathy: Importantly, Chousterman et al. [16] showed that CX3CR1 deficiency reduces the adhesive properties of Ly6Chigh monocytes to endothelium in a kidney damage model during sepsis, demonstrating that the CX3CR1 receptor is involved in monocyte adhesion to the vascular wall; its absence leads to a reduction in inflammatory monocyte adhesion.