Based on routine variables discovered in prostate cancer patients with unfavorable factors, such as high initial PSA (> 20), ISUP Gleason grade group > = 3, positive margin, and higher pathologic T stage, this predictive models could potentially improve the 1 and 5-year BCR prediction after RP, according to the study’s findings and will aid medical professionals in achieving the goal of clinical prediction and creating a proper management for the localized treatment of prostate cancer underwent laparoscopic radical prostatectomy. Here, KLK3 is linked to Familial prostate cancer.