CNOT12 and familial pancreatic carcinoma: In this study, we found that downregulation of TAB182 increases the proliferation, colony formation, migration, and invasion of TNBC cells, consistent with the study of T. Ohishi and colleagues [24], who found a low expression level of TAB182 in pancreatic cancer cells and found that TAB182 deletion played an essential role in cell motility and invasion.