Moreover, the oncogenic mutant p53 exerts an immunosuppressive environment in multiple biological processes, including induction of M2 polarization of macrophages, increase in tumor-associated neutrophil infiltration, decrease in cytotoxic CD8+ T cells and helper CD4+ T cell infiltrations, and increase in fibrosis [25, 38, 53, 54]. The gene discussed is CD8A; the disease is neoplasm.