TP53 and neoplasm: To further illuminate the effects of mutant p53 secretion behavior on tumor microenvironment to exert pro-tumor growth, we constructed 4T-1 cells with knocking-down AP1B1 by shRNA in combination with R270H or alone overexpression of R270H NM (mutated LL28AA in mice) identified by WB in Fig. S6A and the above cells were the deficient types of p53R270H secretion.