IDH1 and astrocytoma (excluding glioblastoma): As shown in Fig. 4A, B, the patients were divided into WHO grade 4 IDH-mutant astrocytoma and IDH-wildtype GBM, and the results showed that the PFS and OS of the WHO grade 4 IDH-mutant astrocytoma were better than IDH-wildtype GBM (P = 0.0336 and P = 0.0324, respectively).