As shown in the boxplot, 18 LAMRs were significantly different between the tumor and normal group, including ACTN3, LDHAL6A, MIR210, PARK7, PFKFB2, PNKD, SLC16A3, SLC16A8, SLC25A12, TIGAR, TP53 were upregulated, and HAGH, LDHA, LDHD, MYC, PER2, SLC16A1, SLC5A12 were downregulated significantly (Fig. 1A). The gene discussed is PFKFB2; the disease is neoplasm.