Elevated levels of IL-6 (> 25.20 pg/mL) have been identified as an independent risk factor for acute exacerbation (OR 1.014 [95% CI 1.001–1.027], p = 0.036) and death (OR 1.007 [95% CI 1.001–1.014], p = 0.018) in patients with interstitial lung disease [35]. This evidence concerns the gene IL6 and interstitial lung disease.