In comparison to the training set, the validation set had older patients (69.00 [61.00, 73.00] vs. 64.00 [57.00, 70.00] years, p = 0.042), a higher prevalence of combined coronary heart disease (24.7% vs. 10.6%, p = 0.029), and lower serum albumin levels (36.50 [33.00, 38.60] vs. 38.90 [35.10, 41.60] g/L, p = 0.001), indicating that the validation results of this study have certain extrapolation validity. The gene discussed is ALB; the disease is coronary artery disorder.