In addition, although the CD8+ T cell population in LT group increased compared to LDH group, there are no significant differences in memory CD8+ T cells (Ly6ChighCD8+ T cells)45, Th1-like memory CD4+ T cells (Ly6ChighCD4+ T cells) and Tfh-like memory CD4+ T cells (Ly6ClowCD4+ T cells)46 between LDH and LT groups, which is essential for preventing tumor relapse or metastasis. The gene discussed is CD4; the disease is neoplasm.