The pathway is also targeted in an ongoing phase III trial investigating the role of the TIM-3 directed antibody sabatolimab (MBG453) in MDS [196], and the combinations of a TIM-3 antibody with the MDM2-inhibitor HDM201 (NCT03940352) or HMA (NCT04623216) are also studied. This evidence concerns the gene MDM2 and myelodysplastic syndrome.