SERPINE1 and deep vein thrombosis: Three of these proteins were estimated to influence DVT risk: Neurogenic locus notch homolog protein 1 (NOTCH1; WR Log RR: 0.57, 95% CI: 0.45 to 0.68; P = 1.12e-23), Plasminogen activator inhibitor-1 (PAI-1; WR Log RR: 0.42, 95% CI: 0.30 to 0.54; P = 4.27e-12) and Inhibin beta C chain (INHBC; WR Log RR: -1.18, 95% CI: -2.18 to -0.69; P = 0.002).