PINK1 and Parkinson disease: PINK1 overexpression not only ameliorated mitochondrial dysfunction resulting from prior induced PINK1 deficiency in PINK1 mutant Drosophila models [71, 280], but also was protective in an aSYN induced phenotype in aSYN transgenic Drosophila PD model [277], and protected against neuronal loss and mitochondrial dysfunction in in vitro and in vivo MPTP models [274].