The weak associations of NfL and p-tau181 with all-cause dementia and the results obtained with GFAP, a marker of reactive astrocytes, shall be interpreted in relation to the nature of the ESTHER cohort, which includes participants with mixed pathology, irrespective of the reported dementia diagnosis, as reported in detail in previous work [20]. The gene discussed is NEFL; the disease is acute lymphoblastic leukemia.