Cyclin D1 protein expression was positively correlated with tumor size (P < 0.05) and lymph node metastasis (P < 0.05), but was not significantly correlated with patient sex, age, number of tumor nests, histological subtype, the presence or absence of chronic lymphocytic thyroiditis or TNM stage (Table 2). This evidence concerns the gene CCND1 and Hashimoto thyroiditis.