BRCA1 and familial pancreatic carcinoma: Previously reported frequencies of BRCA1/2 pathogenic variants in unselected pancreatic cancer patients vary across different populations: 1.2% (12/1009) to 3.2% (16/499) in China [12, 25], 3.4% (34/1005) in Japan [13], 1.2% (5/417) to 6.9% (5/72) in Belgium, Czech Republic [26], Greece [27], Italy [28], UK [5], 1.5% (4/274) to 11.3% (17/151) in the USA [8–11], and 2.3% (4/177) to 4.8% (21/437) in Canada [7, 29].