CL Ho et al. objective circled reprogrammed commensal Escherichia coli Nissle 1917 (EcN) to attach to the heparan sulfate proteoglycan (HSPG) on the cancer cell external surface, then secrete myrosinase to alter dietary glucosinolate to sulforaphane that could limit growth and activate apoptosis in cancer cells. Here, CD44 is linked to cancer.