One case of WM was wild-type with synchronous DLBCL and mutations on CREBBP, EZH2, CARD11, PIM1, SOCS1, STAT6, and TNFRSF14. MYD88 L265P was detected in 50% of SBCL-PC with none of them harboring a CXCR4 mutation or ARID1A mutation. This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.