Then, to clarify the underlying signaling pathway regulated by PRMT1 in cardiac remodeling, we screened some potential signaling pathways that were relevant to cardiac contraction and hypertrophic cardiomyopathy, including p-GSK3β/GSK3β, p-ERK/ERK, p-AKT/AKT and NICD/Notch1 [33–36]. This evidence concerns the gene GSK3B and hypertrophic cardiomyopathy.