Both the sarco-sphere model as well as the corresponding tumor tissue harbored an in-frame EIF5A::USP6 fusion in chromosome 17, homozygous losses of CDKN2A/B and ATRK, a truncation in the NOTCH1 gene and a TCF3::SLC39A3 rearrangement. The gene discussed is EIF5A; the disease is neoplasm.