USP6 and neoplasm: Physiological ex vivo models are important tools for basic and translational research and as these models slowly get integrated into functional precision oncology approaches and clinical decision-making processes, it is of utmost importance that they represent the native tumor from a genotype and phenotype standpointIn the primary tumor, the dermal metastasis and the corresponding ex vivo cell model (USZ20.-ESOS1), an in-frame EIF5A::USP6 fusion was detected.