Other terms that can be found are ‘metformin’ or ‘hypoglycemic agents’, which are used to lower glucose levels in Type 2 diabetes mellitus patients, ‘sirtuin 1’, a protein involved in glucose metabolism and insulin sensitivity (56), and drugs to lower cholesterol levels such as ‘simvastatin’ or ‘HMG-CoA reductase inhibitors’. This evidence concerns the gene INS and type 2 diabetes mellitus.