Interrupting prolonged sitting with 1-min 40-s to 5-min bouts of light or moderate-intensity walking every 20 to 30-min significantly attenuated postprandial cardiometabolic risk markers (e.g., glucose and insulin) in Caucasian participants who are normal-weight or living with overweight and obesity (Champion et al. 2018; Dunstan et al. 2012; Henson et al. 2016; Larsen et al. 2015; Peddie et al. 2013). The gene discussed is INS; the disease is obesity disorder.