INS and obesity due to melanocortin 4 receptor deficiency: In Caucasians living with overweight/obesity, interrupting sitting with light walking for 2 to 5-min every 20 to 30-min attenuated postprandial glucose iAUC by 28% to 32% (Henson et al. 2016; Larsen et al. 2015) and insulin iAUC by 15% to 37% (Dunstan et al. 2012; Henson et al. 2016).