Nowadays, diversity of pathway-based prognosis prediction model is explored and applied in identifying tumor subgroups, such as ferroptosis [7], cuproptosis [7], and immunogenic cell death [8] et al. Recently, anoikis has been reported to be involved in tumor immunity escape [9], and anoikis-related genes (ARGs) are applied to assess tumor immunity in glioblastoma [9] and neck squamous cell carcinoma [10]. This evidence concerns the gene SERPINA2 and neoplasm.