Based on pathway analysis, it shows that Hubgenes close to ARG subtype identification are involved into immunity process, such as interleukin-10 (IL10) and IL17 signaling pathways (Figure 4E, 4F), and are also involved into Wnt signaling pathway and Hippo signaling pathway, both of which participate in drug tolerance process in breast cancer [23–26]. Here, IL10 is linked to breast cancer.