Here, we consider that (1) ARGs-based AI model is useful to assess drug sensitivity in breast cancer; (2) ARGs-based monogram has potential merits for prognosis prediction in breast cancer; (3) An anoikis gene TJP3 promotes chemoresistance, cell migration and immunity escape in breast cancer by regulating EMT and PD-L1 expression. The gene discussed is TJP3; the disease is breast cancer.