It ranks the importance of hub-gene in ARG subgroups identification, and the top3 genes are SFN, TJP3 and TACSTD2 (Figure 7A), amongst while only TJP3 (HR = 1.95, p = 1.3e-8) is prognosis-related gene in breast cancer (Figure 7B). The gene discussed is TACSTD2; the disease is breast cancer.