The latest study on the function of ANXA1 in BLCA has demonstrated that its knockdown prevented PI16’s inhibitory effect on NF-κB activity and cell invasion of BLCA cells, suggesting that ANXA1 might function as a crucial chaperon of PI16 in the control of the NF-κB signaling pathway, and thus participate in the motility and invasion of BLCA cells. Here, PI16 is linked to bladder transitional cell carcinoma.