MAPT and Alzheimer disease: Animal and human studies provide accumulating evidence for an interaction between OSAS and AD pathogenesis by effects of sleep disruption and intermittent hypoxia on amyloid and tau dynamics in cerebrospinal fluid and brain tissue (Bu et al., 2015; Holth et al., 2017; Holth et al., 2019; Ju et al., 2016; Liguori et al., 2017; Liguori et al., 2019; Motamedi et al., 2018; Osorio et al., 2014; Osorio et al., 2015; Spira et al., 2014).