MUC5B and pulmonary fibrosis: Such as, SNP rs35705950 is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, and is involved in the pathogenesis of pulmonary fibrosis by regulating the expression of MUC5B in the lung [15]; SNP rs769236 may be involved in the occurrence of colon cancer, liver cancer and lung cancer by influencing the regulation of CCNA2 expression, and this SNP has been shown to be a valuable biomarker for evaluating individual patients' susceptibility to cancer [16].