Consistent with the diminishing of tau pathology following dox retraction, the hTau-induced cognitive impairments also recovered at 3 months post dox-off (Fig. 5h–k), accompanied by synaptic remodeling (Additional file 1: Fig. S10) and cessation of the hippocampal neuronal loss (Additional file 1: Fig. S11). Here, MAPT is linked to Cognitive impairment.