MAPT and Alzheimer disease: To generate an easy-to-use animal model with accurate simulation of the actual AD tau pathology, we generated a novel hTau368-Tg mouse line, in which the AD-like truncated hTau N1–368 (hTau368) was expressed under the neuron-specific enolase 2 (Eno2) promoter with induction of tetracycline (tet-on).