Thus, insulin treatment of streptozotocin (STZ)-induced DM mice increased EPCs mobilization (Dil-acLDL+ FITC‐UEA‐I+ Sca-1+ c-kit+ Flk-1+) and improved revascularization after hind limb ischemia (HLI), being this effect associated with the regulation of the VEGF/Akt/eNOS and SDF-1/MMP-9 pathway [159]. This evidence concerns the gene VEGFA and diabetes mellitus.