Similarly, the renin inhibitor aliskiren, but not hydrochlorothiazide, improved the vascular function T2DM-hypertensive patients through the reduction of the blood pressure, the increase of the brachial artery flow-mediated dilatation, and the enhancement of the left ventricular function, and it also promoted the augmentation of EPCs (Dil-acLDL+ FITC‐UEA‐I+) levels and the pool of CD34+CD133+ cells [211]. This evidence concerns the gene CD34 and type 2 diabetes mellitus.