Nevertheless, liraglutide improved the in vivo angiogenesis and recovered the blood supply in a murine model of T2DM with HLI, and recovered the in vitro hEPCs (CD144+CD34+VEGFR2+CD14−CD45−) migration and angiogenesis after HGE, being this related to the reduction of oxidative stress and over-expression of the human nuclear factor erythroid 2-related factor 2 (Nrf2) [194]. This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.