The role of the Nrf2 pathway in CDDO-Me-treated N2a cells upon infection with different RABV strains was evaluated, and the expression levels of Nrf2, phospho-SQSTM1, SQSTM1, HO-1 and NQO1 in N2a cells increased to varying degrees in a dose-dependent manner due to CDDO-Me treatment upon infection with SC16, CVS-11 or CTN. The gene discussed is SQSTM1; the disease is infection.