As will follow, our analysis indicates that a number of transcription factors (TFs) can bind to the site of rs17244587 and, rs41515744 polymorphisms to activate or inhibit transcription of TBX21 in the presence of G, A, or G/A alleles for rs17244587 and C, T, or C/T alleles for rs41515744. This may indicate that the TBX21 “depressive” gene could play a role in the pathogenicity of AD from a molecular view:. Here, TBX21 is linked to Alzheimer disease.