Therefore, we analyzed mRNA expression profiles of CD4+ T cells isolated from peripheral blood of healthy individuals, peripheral blood of OC patients and tumor tissues of OC patients, and then found that differential mRNAs in the three groups were significantly enriched in the chemokine-chemokine receptor signaling pathway, suggesting that this pathway may be widely involved in the regulation of biological functions of CD4+ T cells in different locations. This evidence concerns the gene CD4 and neoplasm.