Based on the matching tumor RNA-seq data of NSCLC patients, we identified 405 differentially expressed genes (DEGs) (P.adj < 0.05 and |log2 FC|> 1) between circulating MAPS-high and MAPS-low groups, which can well distinguish the two groups (Fig. 4D). This evidence concerns the gene C3orf62 and non-small cell lung carcinoma.