IGFBP6 and glioblastoma: We identified that Kla production was negatively related to IGFBP6 expression, but Lucia Longhitano et al. indicated that lactate could enhance the expression of IGFBP6, and then induce the microglia M2 polarization in glioblastoma [36], and IGFBP6 induced by lactate promoted glioblastoma cells migration and colony formation.