As shown in Fig. 9A, B, the proportions of naive B cells, regulatory T cells (Treg cells), monocytes, M0/M1 macrophages, eosinophils and neutrophils in SLE samples were significantly increased compared with those in control samples, while the percentages of CD8 T cells, NK cells, dendritic cells and resting mast cells were significantly decreased. Here, CD8A is linked to systemic lupus erythematosus.