From the results of the best algorithm models with different outcomes, it is known that the most important risk factors are: Ccr, ALB, CHA_2DS_2-VACs, DD, AST, NT-pro-BNP, LDH, TSH, CREA, age, UA, DBP, and LAD for any complication, cardiac effusion/tamponade or hemorrhage (Fig. 4). The gene discussed is NPPB; the disease is hemorrhage.